Special low‐protein foods ameliorate postprandial off in patients with advanced Parkinson's disease
Identifieur interne : 001199 ( Main/Exploration ); précédent : 001198; suivant : 001200Special low‐protein foods ameliorate postprandial off in patients with advanced Parkinson's disease
Auteurs : Michela Barichella [Italie] ; Agnieszka Marczewska [Italie] ; Roberta De Notaris [Italie] ; Antonella Vairo [Italie] ; Cinzia Baldo [Italie] ; Andrea Mauri [Italie] ; Chiara Savardi [Italie] ; Gianni Pezzoli [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
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Abstract
Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low‐protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross‐over, single‐blind, pilot clinical trial comparing a 2‐month balanced diet with a 2‐month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 ± 73 min vs. 79 ± 72 min and total off, 164 ± 148 min vs. 271 ± 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 ± 2.7 hr vs. 4.7 ± 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, −1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.21003
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Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1682">1682</biblScope><biblScope unit="page" to="1687">1687</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3A4A030CF40A1D924B24AF4AA1D6A5391EB6D8A3</idno><idno type="DOI">10.1002/mds.21003</idno><idno type="ArticleID">MDS21003</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>diet</term><term>levodopa</term><term>protein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low‐protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross‐over, single‐blind, pilot clinical trial comparing a 2‐month balanced diet with a 2‐month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 ± 73 min vs. 79 ± 72 min and total off, 164 ± 148 min vs. 271 ± 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 ± 2.7 hr vs. 4.7 ± 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, −1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Barichella, Michela" sort="Barichella, Michela" uniqKey="Barichella M" first="Michela" last="Barichella">Michela Barichella</name></region><name sortKey="Baldo, Cinzia" sort="Baldo, Cinzia" uniqKey="Baldo C" first="Cinzia" last="Baldo">Cinzia Baldo</name><name sortKey="Barichella, Michela" sort="Barichella, Michela" uniqKey="Barichella M" first="Michela" last="Barichella">Michela Barichella</name><name sortKey="De Notaris, Roberta" sort="De Notaris, Roberta" uniqKey="De Notaris R" first="Roberta" last="De Notaris">Roberta De Notaris</name><name sortKey="Marczewska, Agnieszka" sort="Marczewska, Agnieszka" uniqKey="Marczewska A" first="Agnieszka" last="Marczewska">Agnieszka Marczewska</name><name sortKey="Mauri, Andrea" sort="Mauri, Andrea" uniqKey="Mauri A" first="Andrea" last="Mauri">Andrea Mauri</name><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><name sortKey="Savardi, Chiara" sort="Savardi, Chiara" uniqKey="Savardi C" first="Chiara" last="Savardi">Chiara Savardi</name><name sortKey="Vairo, Antonella" sort="Vairo, Antonella" uniqKey="Vairo A" first="Antonella" last="Vairo">Antonella Vairo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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